What does it test for ?
The intestines are sometimes referred to as the body’s second brain and play a major role in maintaining our health.
In addition to its well-known role in the digestion and absorption of nutrients, the intestine is a major ecosystem composed of gut microorganisms (or intestinal flora), an immune system (the most important in our body) and a mucous membrane, a mechanical defence barrier.
The balance between gut mucosa, flora and our immune system helps compensate for the physiological or pathological variations caused by infection, inflammation or hyperpermeability. This balance also plays a role in a variety of other chronic inflammatory or auto-immune diseases, regardless of whether or not there are digestive symptoms.
DigestCheck will allow a non-invasive assessment of digestive function and contribute to nutritional analyses seeking to identify intestinal calorie loss or insufficient intake.
It also allows early screening of intestinal inflammation, an imbalance of the intestinal flora or abnormalities in intestinal permeability (via microscopic tears in the intestinal walls) that can cause many disorders, such as irritable bowel syndrome, food intolerances, autoimmune diseases and chronic intestinal inflammations.
Who is it intended for ?
This panel is universal and is particularly useful for people presenting digestive problems and those presenting symptoms possibly due to an imbalance in the digestive ecosystem.
This test is intended for anyone presenting digestive disorders or syndromes that could result from an imbalance in the digestive ecosystem:
- unexplained intestinal pain, diarrhoea, chronic constipation,
- chronic intestinal inflammation (including Crohn’s disease), irritable bowel syndrome, coeliac’s disease, diverticulitis, etc…
- post-surgery, post-radiotherapy digestive nutritional assay,
- individuals with issues related to repeated or long-term use of antibiotics, anti-inflammatory agents or proton-pump inhibitors,
- food intolerances,
- chronic inflammatory diseases (joint or otherwise),
- depression, anxiety, etc.
What does it examine ?
The screening examines four main areas:
- inflammation originating from the intestines: faecal assay of calprotectin and beta-2 defensin,
- increased intestinal permeability: assay of zonulin and alpha-1-antitrypsin,
- imbalances in gut flora or dysbiosis: candida serology,
- evaluation of immune defence of the intestinal mucosa via faecal secretory IgA assay,
- identifying food intolerances: assays of total IgA and anti-transglutaminase IgA.
The assay of food IgGs, used to investigate a suspected food intolerance, can identify a major source of chronic inflammation linked to IgG production.
Note: the testing of food IgG antibodies for suspected food intolerances can help identify an important source of chronic inflammation related to the production of IgG antibodies. Depending on your symptoms and results of other tests, it may be relevant to perform an IgG food intolerance panel in addition to GICheck.